Description

Levcromakalim is a potent potassium channel activator belonging to the benzopyran chemical class. This compound is of significant interest in pharmaceutical research and development due to its vasodilatory properties. It serves as a critical intermediate and reference standard for researchers and manufacturers in the life sciences sector, particularly those focused on cardiovascular pharmacology and smooth muscle physiology.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified material for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the production of advanced cardiovascular research compounds.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate potassium (K+) channel function, vascular tone regulation, and smooth muscle relaxation mechanisms.
• Preclinical Development: Utilized in the discovery and development phases of new therapeutic agents targeting hypertension, angina, and other conditions related to vascular resistance.
• Life Science Reagent: Supplied to academic institutions, contract research organizations (CROs), and pharmaceutical companies for specialized research programs.

Basic Information

Product Name	Levcromakalim
CAS No.	94535-50-9
Molecular Formula	C13H16N2O3
Molecular Weight	248.28 g/mol
Synonyms	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile; (-)-Cromakalim; (3S,4R)-Cromakalim; Levcromakalim [USAN]; BRL 38227; (3S-trans)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; The (-)-enantiomer of Cromakalim
EINECS	Contact for details

Quality Control

Our Levcromakalim is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of chiral purity to ensure the specified enantiomeric excess. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle and store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.