Description

Isosorbide 2-Mononitrate is a key organic nitrate compound widely utilized as a pharmaceutical intermediate. Its primary commercial value lies in its role as a precursor in the synthesis of cardiovascular medications, particularly vasodilators used to treat angina pectoris. This high-purity chemical is essential for manufacturers in the pharmaceutical and fine chemical industries requiring reliable, specification-grade raw materials for API production.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of isosorbide mononitrate and dinitrate APIs for anti-anginal drugs.
• Vasodilator Prodrug Synthesis: Serves as a direct precursor in manufacturing medications that release nitric oxide to dilate blood vessels and relieve chest pain.
• Cardiovascular Research: Used in R&D laboratories for developing new nitrate-based therapeutic agents and studying coronary vasodilation mechanisms.
• Fine Chemical Synthesis: Employed in organic synthesis routes requiring a high-purity nitrate ester functionality.
• Controlled-Release Formulation Development: Acts as an active model compound in the research of sustained-release oral dosage forms.

Basic Information

Product Name	Isosorbide 2-Mononitrate
CAS No.	16106-20-0
Molecular Formula	C6H9NO6
Molecular Weight	191.14 g/mol
Synonyms	1,4:3,6-Dianhydro-D-glucitol 2-nitrate; ISMN; Isosorbide-2-nitrate; 2-Isosorbide Mononitrate; D-Isosorbide 2-Mononitrate; (3R,3aR,6S,6aR)-6-Nitrooxyhexahydrofuro[3,2-b]furan-3-ol; 2-Nitrooxy-1,4:3,6-dianhydro-D-glucitol
EINECS	240-289-6

Quality Control

Our Isosorbide 2-Mononitrate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets exacting standards suitable for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.