Description

(R)-Ranolazine CAS NO 114246-80-9 is the single enantiomer of the antianginal drug ranolazine, representing a high-purity chiral intermediate and active pharmaceutical ingredient (API). This compound is critical for the development and manufacturing of enantiomerically pure cardiovascular therapeutics, offering superior specificity and reduced side-effect profiles compared to racemic mixtures. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers focused on innovative cardiology treatments and chiral synthesis.

Application

• Key chiral intermediate for the synthesis of enantiomerically pure ranolazine API.
• Active Pharmaceutical Ingredient (API) in advanced cardiovascular drug formulations for chronic angina treatment.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Building block in medicinal chemistry research for novel late sodium current inhibitors.
• Substrate for pharmacokinetic and metabolic studies to understand enantiomer-specific effects.
• Starting material for the preparation of deuterated or other isotopically labeled ranolazine analogs for research.

Basic Information

Product Name	(R)-Ranolazine
CAS No.	114246-80-9
Molecular Formula	C24H33N3O4
Molecular Weight	427.54 g/mol
Synonyms	(R)-(+)-Ranolazine; (2R)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; (R)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; (R)-CVT 303; Ranolazine R-enantiomer; UNII-33M5U344CJ
EINECS	Contact for details

Quality Control

Our (R)-Ranolazine is manufactured under strict quality management systems. Each batch is tested to ensure high chemical and enantiomeric purity, meeting the rigorous standards required for pharmaceutical development. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, impurity profile, and chiral purity, supporting regulatory filings from IND to NDA stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.