Description

Ranolazine CAS NO 110445-25-5 is a piperazine derivative and a selective late sodium current inhibitor used as an anti-anginal agent. This compound is critical for the development and manufacturing of pharmaceutical formulations targeting chronic angina pectoris. It is primarily required by pharmaceutical companies, research institutions, and contract manufacturing organizations (CMOs) engaged in cardiovascular drug production and advanced medical research.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of finished dosage forms for the treatment of chronic angina.
• Cardiovascular Research: A key reference standard and tool compound in preclinical and clinical studies investigating myocardial ischemia and arrhythmias.
• Generic Drug Manufacturing: Sourcing of high-purity Ranolazine for the production of bioequivalent generic versions of branded anti-anginal medications.
• Formulation Development: Used in R&D labs for developing new drug delivery systems, such as extended-release tablets, to optimize therapeutic efficacy.
• Analytical Testing: Serves as a primary standard in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.

Basic Information

Product Name	Ranolazine
CAS No.	110445-25-5
Molecular Formula	C24H33N3O4
Molecular Weight	427.54 g/mol
Synonyms	CVT 303; RS 43285; (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; Ranexa (Brand Name); 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-; Ranolazine Hydrochloride (Salt form precursor)
EINECS	Contact for details

Quality Control

Our Ranolazine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications typically referencing pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.