Description

Bimakalim CAS NO 117545-11-6 is a high-purity potassium channel activator belonging to the benzopyran chemical class. This compound is of significant interest in pharmaceutical research and development for its vasodilatory properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular and metabolic disease research.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in preclinical studies.
• Cardiovascular Pharmacology: Investigated for its potential as a potassium channel opener in studies related to hypertension, angina, and ischemic heart disease.
• Metabolic Disorder Studies: Used in research exploring potassium channel function in insulin secretion and potential treatments for diabetes.
• Biochemical Assay Development: Employed as a precise tool compound for validating assays targeting ATP-sensitive potassium (KATP) channels.
• Academic Research: Utilized in university and institutional labs for fundamental studies on smooth muscle relaxation and cellular electrophysiology.
• GMP Manufacturing: Supplied as a high-quality starting material or intermediate for cGMP-compliant production of novel therapeutic agents.

Basic Information

Product Name	Bimakalim
CAS No.	117545-11-6
Molecular Formula	C13H17N3O3
Molecular Weight	263.29 g/mol
Synonyms	(+)-Bimakalim; Bimakalim, (+)-; BMS-180448; (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-3-ol; SR 44800; Potassium channel opener Bimakalim
EINECS	Contact for details

Quality Control

Our Bimakalim is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.