Description

Cromakalim is a potent and selective potassium channel activator belonging to the benzopyran chemical class. This compound is of significant interest in pharmacological research for its vasodilatory and cardioprotective properties. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for researchers and developers in the pharmaceutical and life sciences industries.

Application

• Pharmacological Research: Used as a reference standard in studies investigating potassium channel physiology and pharmacology.
• Cardiovascular Drug Development: Serves as a key intermediate or lead compound in the synthesis of novel antihypertensive and anti-anginal agents.
• Vasodilator Studies: Employed in preclinical research to study mechanisms of smooth muscle relaxation and peripheral vasodilation.
• API Synthesis: Acts as a building block in the multi-step synthesis of advanced pharmaceutical compounds targeting ion channels.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro assays to identify and characterize new potassium channel modulators.

Basic Information

Product Name	Cromakalim
CAS No.	94470-67-4
Molecular Formula	C16H19NO4
Molecular Weight	289.33 g/mol
Synonyms	(+)-Cromakalim; BRL 34915; (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-3-ol; (3S-trans)-3,4-Dihydro-6-cyano-2,2-dimethyl-3-hydroxy-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran
EINECS	Contact for details

Quality Control

Our Cromakalim is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.