Description

n-Propionyl Mesalazine is a chemically modified derivative of mesalazine (5-aminosalicylic acid), designed to offer enhanced stability and targeted delivery. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a prodrug in the treatment of inflammatory bowel diseases. It serves as a critical intermediate for researchers and manufacturers developing next-generation, site-specific therapeutic agents. The global market for this specialized intermediate is driven by innovation in gastroenterology and precision medicine.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the production of novel mesalazine prodrugs.
• Research & Development: Utilized in academic and industrial labs for studying drug metabolism, stability, and targeted release mechanisms.
• Gastroenterology Drug Development: A crucial building block for creating enhanced formulations aimed at treating ulcerative colitis and Crohn's disease.
• Controlled-Release Formulations: Investigated for its utility in developing colon-specific drug delivery systems to improve therapeutic efficacy and reduce systemic side effects.
• Chemical Synthesis: Serves as a protected or modified intermediate in complex organic synthesis routes within fine chemical manufacturing.

Basic Information

Product Name	n-Propionyl Mesalazine
CAS No.	93968-80-0
Molecular Formula	C11H13NO5
Molecular Weight	239.23 g/mol
Synonyms	5-(Propionylamino)-2-hydroxybenzoic Acid; Mesalazine Propionate; 5-Aminosalicylic Acid N-Propionate; 5-ASA Propionate; N-Propionyl-5-aminosalicylic Acid; 2-Hydroxy-5-(propionylamino)benzoic Acid; Propionyl Mesalamine
EINECS	Contact for details

Quality Control

Our n-Propionyl Mesalazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.