Description

β-Philanthotoxin is a potent, naturally occurring neurotoxin originally isolated from the venom of the digger wasp (*Philanthus triangulum*). This compound is a valuable research-grade biochemical tool used to study and characterize ionotropic glutamate receptors, particularly the AMPA and kainate subtypes. It is essential for neuroscientists, pharmacologists, and biochemists conducting fundamental research in neurophysiology, synaptic transmission, and the development of novel therapeutic agents targeting neurological disorders.

Application

• Neuroscience Research: As a selective, non-competitive antagonist for studying the function and pharmacology of AMPA and kainate-type glutamate receptors in neuronal circuits.
• Pharmacological Profiling: Used in high-throughput screening (HTS) assays to identify and evaluate new compounds that modulate ionotropic glutamate receptor activity.
• Electrophysiology Studies: A critical tool for patch-clamp experiments to investigate receptor kinetics, desensitization, and channel block mechanisms.
• Neuroprotection Research: Employed in models of excitotoxicity to understand glutamate-induced neuronal damage and to test potential neuroprotective agents.
• Biochemical Assay Development: Serves as a reference standard in the development and validation of binding assays for glutamate receptor subtypes.
• Academic & Institutional Research: Fundamental research in universities and institutes focused on understanding synaptic plasticity, learning, and memory.

Basic Information

Product Name	β-Philanthotoxin
CAS No.	93196-67-9
Molecular Formula	C19H33N5O4
Molecular Weight	395.50 g/mol
Synonyms	PhTX; Philanthotoxin-433; β-PhTX; Philanthotoxin β; 4-Hydroxyphenylacetylasparaginylspermine; N-[4-[[(2-Amino-3-hydroxy-1-oxobutyl)amino]carbonyl]-1-(4-aminobutyl)-4,9-diazadodec-1-yl]-4-hydroxybenzeneacetamide
EINECS	Contact for details

Quality Control

Our β-Philanthotoxin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical data is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Solutions should be prepared fresh or aliquoted and stored frozen for single use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 98%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Methanol, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.