Description

Amorphadiene CAS NO 92692-39-2 is a key biosynthetic intermediate in the isoprenoid pathway, serving as the direct precursor to artemisinin, a vital antimalarial compound. Its controlled synthesis and supply are critical for ensuring the reliability and scalability of artemisinin-based combination therapies (ACTs). This high-purity intermediate is essential for pharmaceutical manufacturers, biotechnology research labs, and academic institutions focused on synthetic biology, metabolic engineering, and the development of novel therapeutics.

Application

• Artemisinin Biosynthesis: The primary and most significant application is as the dedicated precursor in the engineered microbial or plant-based production of artemisinic acid and subsequently artemisinin.
• Pharmaceutical Intermediate: Serves as a critical building block in the semi-synthesis of artemisinin and its derivatives (e.g., artemether, artesunate) for antimalarial drugs.
• Metabolic Engineering Research: Used as a standard and substrate in studies aimed at optimizing yeast (e.g., *Saccharomyces cerevisiae*) and other microbial platforms for terpenoid production.
• Synthetic Biology: A key compound for developing and testing novel enzymatic pathways and genetic circuits designed for high-value isoprenoid manufacturing.
• Biochemical Reference Standard: Employed in analytical laboratories for method development, calibration, and quantification in LC-MS, GC-MS, and HPLC analyses related to terpene metabolism.
• Academic & Industrial R&D: Fundamental research into sesquiterpene synthases, cytochrome P450 enzymes, and the broader isoprenoid biosynthetic network.

Basic Information

Product Name	Amorphadiene
CAS No.	92692-39-2
Molecular Formula	C15H24
Molecular Weight	204.35 g/mol
Synonyms	(1E,6E,10R)-2,6,10-Trimethyl-1,6,10-dodecatriene; (1E,6E)-2,6,10-Trimethyl-1,6,10-dodecatriene; Amorphadiene; Artemisinic alcohol precursor; Amorpha-4,11-diene (common biosynthetic name); FPP-derived sesquiterpene; Artemisinin precursor
EINECS	Contact for details

Quality Control

Our Amorphadiene is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive pharmaceutical and biotechnological applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. For long-term storage, keep at -20°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and volatile loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (GC-MS)	Conforms to reference standard
Purity (by GC or HPLC)	≥ 95.0%
Related Substances (Impurities)	≤ 5.0% total
Specific Rotation (if applicable)	Contact for details
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.