Description

Insulin, Leu(B30)- is a synthetic insulin analogue where the B-chain's 30th amino acid is leucine. This modification is of significant interest in pharmaceutical research for studying insulin structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in diabetes research, peptide chemistry, and the development of advanced insulin formulations.

Application

• Pharmaceutical Research & Development: As a key reference standard and intermediate in the study of insulin's biological activity and receptor binding mechanisms.
• Structure-Activity Relationship (SAR) Studies: To investigate the impact of specific amino acid substitutions on insulin's potency, stability, and pharmacokinetic profile.
• Bioconjugation & Protein Engineering: Serving as a substrate for developing site-specifically modified insulin conjugates for enhanced therapeutic properties.
• Analytical Standard: Used in high-performance liquid chromatography (HPLC) and mass spectrometry for the identification and quantification of insulin variants.
• Preclinical Studies: Employed in metabolic and pharmacological research to evaluate novel diabetes treatment strategies.

Basic Information

Item	Details
Product Name	Insulin, Leu(B30)-
CAS No.	92679-50-0
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Leu(B30)-Insulin; Insulin B30-Leucine; [LeuB30]-Insulin; Human Insulin (LeuB30); Insulin, Leu30-B-chain; Insulin analogue (B30 Leu); B30-Leucine Insulin; Insulin (Leu for Thr at B30)
EINECS	Contact for details

Quality Control

Our Insulin, Leu(B30)- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and peptide mapping for identity confirmation, to ensure it meets high-purity research-grade standards. A Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.