Description

Mono-Methyl Polyethylene Glycol 20'000 2-(Succinyl-Amino)Ethyl Ether is a high-purity, functionalized PEG derivative designed for advanced bioconjugation and pharmaceutical applications. This compound matters because it provides a reactive succinyl-amino linker for the stable attachment of active molecules, such as proteins or drugs, while the monomethyl PEG chain offers superior stealth properties and solubility. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reproducible PEGylation to enhance therapeutic efficacy, reduce immunogenicity, and improve pharmacokinetic profiles.

Application

• Pharmaceutical PEGylation: Conjugation to therapeutic proteins, peptides, and antibody fragments to prolong circulation half-life and reduce immunogenicity.
• Drug Delivery Systems: Synthesis of prodrugs and construction of polymer-drug conjugates for targeted and controlled release applications.
• Diagnostic Reagent Modification: Functionalization of enzymes, antibodies, and other biomolecules used in assay kits and imaging agents.
• Biomaterial Surface Engineering: Creating non-fouling, biocompatible coatings on medical devices and implants.
• Linker Chemistry in Bioconjugation: Serving as a heterobifunctional crosslinker with an amine-reactive succinyl group for creating stable amide bonds.
• Nanoparticle Functionalization: Modifying the surface of liposomes, micelles, and polymeric nanoparticles to improve stability and biodistribution.

Basic Information

Product Name	Mono-Methyl Polyethylene Glycol 20'000 2-(Succinyl-Amino)Ethyl Ether
CAS No.	92450-99-2
Molecular Formula	C2n+6H4n+14NOn+5 (n~454)
Molecular Weight	~20,000 g/mol
Synonyms	mPEG-Succinyl-NH2; mPEG20k-SC-NH2; Methoxy PEG Succinimidyl Carboxylate Amine; α-Methyl-ω-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethylamino)ethoxy)poly(oxyethylene); PEG-OMe Succinimidyl Carboxymethyl Ester Amine; mPEG-NHS Ester Amine Derivative; Poly(ethylene glycol) methyl ether succinimidyl carboxymethyl ester amine; mPEG-SCM-NH2
EINECS	Contact for details

Quality Control

Our Mono-Methyl Polyethylene Glycol 20'000 2-(Succinyl-Amino)Ethyl Ether is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group assay, NMR for structural confirmation, and GPC for molecular weight distribution. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the active ester group.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Molecular Weight (GPC)	Mn: 19,000 - 21,000 Da; PDI: ≤ 1.05
Assay (Functional Group, Titration)	≥ 95%
Purity (HPLC)	≥ 98.0%
Moisture Content (KF)	≤ 1.0%
Solubility (1% in Water)	Clear, colorless solution
Endotoxin (LAL)	< 0.1 EU/mg (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.