Description

Dioleoylphosphatidylthioglycerol is a synthetic, sulfur-containing phospholipid derivative. This specialized compound is valued for its unique chemical structure, which combines the properties of phosphatidylglycerol with a thioether linkage, offering distinct reactivity and membrane-interaction capabilities. It is primarily utilized in advanced pharmaceutical research and development, particularly in the formulation of novel drug delivery systems such as liposomes and lipid nanoparticles.

Application

• Liposomal Drug Delivery: A key functional excipient for constructing targeted and sustained-release liposomal formulations.
• Biomimetic Membrane Studies: Used in model membrane systems to study the effects of thioether lipids on bilayer structure and permeability.
• Surface Functionalization: Serves as an anchor molecule on nanoparticle surfaces for subsequent conjugation with targeting ligands or therapeutic agents.
• Gene Delivery Vectors: A component in non-viral vector systems designed for improved cellular uptake and endosomal escape of nucleic acids.
• Diagnostic Agent Formulation: Incorporated into contrast agents or probes for imaging applications to enhance stability and biodistribution.
• Bioconjugation Chemistry: The thioether group provides a handle for specific chemical modifications and cross-linking reactions.

Basic Information

Product Name	Dioleoylphosphatidylthioglycerol
CAS No.	91860-73-0
Molecular Formula	C44H81O9PS
Molecular Weight	817.15 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phosphothioglycerol; DOPTG; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-thioglycerol); Phosphatidylthioglycerol, dioleoyl derivative; Thiophosphatidylglycerol; Sulfur-containing phospholipid; (2,3-Dihydroxypropyl) [2,3-bis[[(9Z)-octadec-9-enoyl]oxy]propyl] hydrogen phosphorothioate
EINECS	Contact for details

Quality Control

Our Dioleoylphosphatidylthioglycerol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, ethanol; forms dispersions in aqueous buffers
Heavy Metals	< 10 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.