Description

6-Fluorovitamin D3 is a fluorinated analog of Vitamin D3, a key intermediate in the synthesis of novel vitamin D receptor modulators. This compound is valued for its role in developing targeted therapeutics and research tools due to the unique properties imparted by the fluorine atom. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on metabolic bone disease research, cancer studies, and the development of new hormonal therapies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation Vitamin D analogs and calcitriol derivatives with enhanced metabolic stability.
• Biochemical Research: Used as a probe to study the structure-activity relationship (SAR) of the Vitamin D receptor (VDR) and its signaling pathways.
• Drug Discovery: Serves as a key precursor in developing novel therapeutics for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation of related compounds.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value fluorinated steroidal compounds.

Basic Information

Product Name	6-Fluorovitamin D3
CAS No.	91625-75-1
Molecular Formula	C₂₇H₄₃FO
Molecular Weight	402.63 g/mol
Synonyms	(5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3β-ol, 6-fluoro-; 6-Fluoro-9,10-secocholesta-5,7,10(19)-trien-3β-ol; 6-Fluoro-cholecalciferol; 6-Fluoro Vitamin D3; 6-Fluoro-D3; 6-F-Cholecalciferol; Fluorocalciferol
EINECS	Contact for details

Quality Control

Our 6-Fluorovitamin D3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C or as specified on the label or COA. Keep the container in a cool, dry, and well-ventilated area, away from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.