Description

1-Boc-4-Cyanopiperidine is a versatile and high-purity chemical intermediate, widely recognized for its role in modern synthetic organic chemistry. Its value lies in the dual functionality of the Boc-protected amine and the cyano group, which allows for selective transformations and the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, serving as a critical building block for active pharmaceutical ingredients (APIs), ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those containing piperidine scaffolds, such as kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the piperidine moiety contributes to biological activity.
• Peptide Mimetics & Conjugates: The protected amine is instrumental for creating peptide analogs and bioconjugates, enabling the introduction of the cyano-piperidine unit into larger biomolecules.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and library production for high-throughput screening.
• Academic & Industrial Research: A fundamental reagent in medicinal chemistry labs and R&D departments for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	1-Boc-4-Cyanopiperidine
CAS No.	91419-52-2
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-cyanopiperidine; 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-cyanopiperidine-1-carboxylate; 1-Boc-4-cyano-piperidine; N-Boc-4-cyanopiperidine; 4-Cyano-1-N-Boc-piperidine; 1-N-Boc-4-cyanopiperidine; Piperidine-1-carboxylic acid, 4-cyano-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Cyanopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with the standards expected in pharmaceutical R&D and production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.