Description

Insulin, Asn(B10)- CAS NO 91315-00-3 is a specific, single-point mutant of human insulin where the amino acid at position B10 has been substituted with asparagine. This engineered analog is of significant scientific and pharmaceutical interest for studying insulin's structure-function relationships and receptor binding mechanisms. It is primarily utilized by research institutions and biotechnology companies focused on diabetes research, metabolic studies, and the development of novel insulin-based therapeutics.

Application

• Biomedical Research: A critical tool for investigating insulin signaling pathways, receptor affinity, and the molecular basis of diabetes.
• Pharmaceutical Development: Serves as a reference compound and intermediate in the R&D of next-generation insulin analogs with modified pharmacokinetic profiles.
• Structure-Activity Relationship (SAR) Studies: Used to elucidate the impact of specific amino acid residues on insulin's stability, aggregation, and biological activity.
• Analytical Standard: Employed as a high-purity reference standard in chromatographic (HPLC, UPLC) and mass spectrometric analyses for quality control.
• Biochemical Assays: Essential for in vitro and cell-based assays to test insulin receptor activation and downstream metabolic effects.

Basic Information

Product Name	Insulin, Asn(B10)-
CAS No.	91315-00-3
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Human Insulin [Asn(B10)]; [AsnB10]-Human Insulin; Insulin (human) B10-Asn mutant; Insulin B10-Asn; Asn(B10)-Insulin; Insulin AsnB10; Insulin mutant AsnB10; B10-Asn Insulin Analog
EINECS	Contact for details

Quality Control

Our Insulin, Asn(B10)- is produced and handled under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity and peptide mapping for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Proteins (HPLC)	≤ 5.0%
Water Content (Karl Fischer)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay (Contact for details)
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.