Description

Insulin, Gln(B30)- is a high-purity, synthetic insulin analogue where the amino acid at position B30 has been substituted with glutamine. This specific modification is of significant interest in pharmaceutical research and development for studying insulin structure-activity relationships and receptor binding. It serves as a critical intermediate and reference standard for the development of novel insulin-based therapeutics. This product is essential for researchers and manufacturers in the biopharmaceutical sector focused on diabetes treatment and metabolic disorder research.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis and study of novel insulin analogues with modified pharmacokinetic profiles.
• Reference Standard: For analytical method development, validation, and quality control testing of insulin-based drug substances and products.
• Biochemical Studies: To investigate the impact of specific amino acid substitutions on insulin's biological activity, receptor affinity, and stability.
• Process Development: Used in scaling up production processes for next-generation insulin therapeutics in GMP environments.
• Academic Research: A vital tool for universities and research institutes studying protein engineering, peptide chemistry, and diabetes pathophysiology.

Basic Information

Product Name	Insulin, Gln(B30)-
CAS No.	91261-12-0
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5807.5 g/mol
Synonyms	B30-Gln Insulin; [GlnB30]-Insulin; Insulin (human) B30-Gln analogue; Insulin Gln(B30); Insulin analogue B30-Gln; Glutamine-B30 Insulin; Human Insulin [GlnB30]; Insulin, 30B-L-glutamine-
EINECS	Contact for details

Quality Control

Our Insulin, Gln(B30)- is produced and tested to meet exacting standards for research and development use. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from tests including HPLC purity, peptide mapping, mass spectrometry, and related substances. We adhere to stringent quality management protocols suitable for supporting pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Related Substances	≤ 5.0%
Water Content (KF)	≤ 10.0%
Peptide Content	≥ 80.0%
Biological Activity	Assessed by specific assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.