Description

4-Hydroxyestradiol 17-Sulfate is a sulfated metabolite of estradiol, a key endogenous estrogen. This compound is of significant value as a high-purity reference standard and biochemical tool for research and diagnostic applications. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of in-vitro diagnostic kits for studying estrogen metabolism, hormone-related diseases, and developing analytical methods.

Application

• Biochemical Research: Used as a critical reference standard in studies of estrogen sulfation pathways, metabolic profiling, and endocrine system function.
• Pharmaceutical Development: Serves as an analytical standard in the development and quality control of hormone-based therapeutics and in pharmacokinetic studies.
• Clinical Diagnostics: Employed as a calibrator or control in the development and validation of LC-MS/MS and immunoassay methods for quantifying steroid hormones in biological samples.
• Metabolomics: A key analyte in targeted metabolomics panels focused on steroidogenesis and endocrine disruption research.
• Academic Research: Utilized in university and institutional labs for fundamental research into cancer biology, reproductive health, and metabolic disorders linked to estrogen signaling.

Basic Information

Product Name	4-Hydroxyestradiol 17-Sulfate
CAS No.	90746-92-2
Molecular Formula	C18H22O6S
Molecular Weight	366.43 g/mol
Synonyms	Estra-1,3,5(10)-triene-3,4,17β-triol 17-sulfate; 4-Hydroxy-17β-estradiol 17-sulfate; 3,4,17β-Trihydroxyestra-1,3,5(10)-trien-17-yl sulfate; 4-Hydroxyestradiol sulfate; 4-OHE2-17S; 17β-Estradiol-3,4,17-triol 17-sulfate
EINECS	Contact for details

Quality Control

Our 4-Hydroxyestradiol 17-Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.