Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-L-Serine (Sodium Salt) is a high-purity, synthetic phospholipid derivative of phosphatidylserine (PS). This compound is a critical functional component in the formulation of advanced lipid-based delivery systems, particularly liposomes and lipid nanoparticles (LNPs). It is essential for research and commercial applications in the pharmaceutical, biotechnology, and advanced materials sectors where membrane interaction, targeted delivery, and biocompatibility are paramount.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key anionic lipid component for constructing stable, functional vesicles for drug and gene delivery (e.g., mRNA vaccines, siRNA therapeutics).
• Biomimetic Membrane Research: Used to create model cell membranes that incorporate phosphatidylserine for studies on apoptosis, cell signaling, and protein-lipid interactions.
• Drug Delivery Targeting: Exploits the "eat-me" signal of externalized PS for targeting macrophages or specific receptors in diseased tissues.
• Diagnostic Reagent Preparation: Serves as a critical raw material in the production of diagnostic assays and kits that rely on membrane-based detection.
• Cosmetic & Dermal Formulations: Incorporated into high-end cosmetic products for its skin barrier repair and moisturizing properties.
• Biochemical & Cell Culture Supplements: Used as a supplement in cell culture media to study neuronal function and membrane dynamics.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-L-Serine (Sodium Salt)
CAS No.	90693-88-2
Molecular Formula	C42H78NO10PNa
Molecular Weight	810.03 g/mol
Synonyms	DOPS (Sodium Salt); 1,2-Dioleoyl-sn-glycero-3-phosphoserine sodium salt; 18:1 PS (Sodium Salt); Phosphatidylserine (DOPS, Na Salt); L-α-Phosphatidylserine (Sodium Salt), Dioleoyl; (2S)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (2S)-2-amino-3-phosphonooxypropanoate sodium salt; Sodium 1,2-dioleoyl-sn-glycero-3-phospho-L-serinate
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho-L-Serine (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and life science research. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Solubility	Soluble in chloroform, methanol, ethanol; forms dispersions in water
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.