Description

(1Ar,4E,8E,11S,11Ar,14As,14Br)-2,3,6,7,10,11,11A,12,14A,14B-Decahydro-11-Hydroxy-1A,5,9-Trimethyl-12-Methyleneoxireno[13,14]Cyclotetradeca[1,2-B]Furan-13(1Ah)-One is a complex, high-purity sesquiterpene lactone derivative with a unique oxireno-fused cyclotetradecane structure. This compound is valued for its sophisticated molecular architecture, which serves as a critical advanced intermediate in the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing new therapeutic agents and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of new drug candidates, particularly in oncology and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and scaffold-hopping studies to explore novel chemical space and improve pharmacokinetic properties.
• Synthetic Organic Chemistry: Serves as a complex starting material or intermediate for total synthesis projects and methodological studies involving polycyclic systems.
• Biochemical Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• High-Value Fine Chemical Production: Incorporated into the synthesis of specialty chemicals requiring specific, complex stereochemistry.
• Academic & Institutional Research: Employed in universities and research institutes for cutting-edge chemical and pharmacological studies.

Basic Information

Product Name	(1Ar,4E,8E,11S,11Ar,14As,14Br)-2,3,6,7,10,11,11A,12,14A,14B-Decahydro-11-Hydroxy-1A,5,9-Trimethyl-12-Methyleneoxireno[13,14]Cyclotetradeca[1,2-B]Furan-13(1Ah)-One
CAS No.	90523-38-9
Molecular Formula	C20H28O4
Molecular Weight	332.43 g/mol
Synonyms	11-Hydroxy-1A,5,9-trimethyl-12-methyleneoxireno[13,14]cyclotetradeca[1,2-b]furan-13(1Ah)-one; Parthenolide analog; Parthenolide derivative; Oxireno-fused sesquiterpene lactone; Advanced sesquiterpene intermediate; CAS 90523-38-9; (11S)-11-Hydroxy-1A,5,9-trimethyl-12-methylidene-14-oxatetracyclo[10.3.1.0^{1,10}.0^{4,9}]hexadec-4-ene-13,16-dione (IUPAC alternative)
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols suitable for research and development applications. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP compliance for pharmaceutical development, ensuring traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound may be sensitive to prolonged exposure to heat, moisture, and strong oxidizing agents. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.