Description

Hydroxy-Peg3-Methylamine is a versatile bifunctional PEG linker featuring a terminal primary amine and a hydroxyl group, separated by a triethylene glycol spacer. This compound is essential for bioconjugation, enabling the controlled attachment of biomolecules, drugs, or labels while improving solubility and reducing immunogenicity. It is a critical building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science.

Application

• Bioconjugation and Cross-linking: Used to conjugate peptides, proteins, antibodies, or oligonucleotides to drugs, fluorophores, or solid surfaces.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component to connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Modifies therapeutic proteins and peptides to enhance pharmacokinetic properties such as circulation half-life and stability.
• Polymer and Dendrimer Synthesis: Acts as a functional monomer or branching unit for creating biocompatible polymers and nanostructures.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chromatography media with amine-reactive or hydroxyl-reactive groups.
• Diagnostic Reagent Formulation: Incorporated into assay components for diagnostic kits to improve performance and stability.

Basic Information

Product Name	Hydroxy-Peg3-Methylamine
CAS No.	90430-59-4
Molecular Formula	C9H21NO4
Molecular Weight	207.27 g/mol
Synonyms	2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-amine), 3,6-Dioxa-1,8-octanediamine, 1-Amino-3,6,9-trioxaundecan-11-ol, 11-Amino-3,6,9-trioxaundecan-1-ol, H2N-PEG3-OH, Amino-PEG3-alcohol, 3,6,9-Trioxaundecane-1,11-diol, 1-amine
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-Methylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive applications like bioconjugation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.