Description

3-o-Hexadecyl-Sn-Glycero-1-Phosphocholine is a synthetic, high-purity phospholipid analog, specifically a lysophosphatidylcholine derivative with a palmitoyl (C16:0) chain at the sn-3 position. This precise molecular structure makes it a critical building block for advanced lipid-based research and formulation development. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require defined lipid components for creating liposomes, lipid nanoparticles (LNPs), and other biomimetic membrane systems.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural and functional lipid component in the development of mRNA and siRNA delivery systems for therapeutic applications.
• Liposome & Model Membrane Research: Used to create defined liposomal bilayers and vesicles for drug delivery studies, membrane protein reconstitution, and biophysical research on membrane dynamics.
• Biochemical & Cell Biology Reagents: Serves as a substrate or modulator in enzymatic studies involving phospholipases and lipid metabolism pathways.
• Pharmaceutical Excipient Development: Investigated for its surfactant and membrane-fusogenic properties in enhancing drug solubility and cellular uptake.
• Cosmetic & Dermal Delivery Systems: Incorporated into advanced nano-carrier systems for the targeted and sustained release of active ingredients in skincare formulations.
• Diagnostic Assay Development: Utilized in the fabrication of biosensors and diagnostic platforms that require stable, functionalized lipid layers.

Basic Information

Product Name	3-o-Hexadecyl-Sn-Glycero-1-Phosphocholine
CAS No.	90130-75-9
Molecular Formula	C₂₄H₅₂NO₆P
Molecular Weight	481.65 g/mol
Synonyms	1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine; 3-O-Hexadecyl-sn-glycero-1-phosphorylcholine; Lyso-PAF C-16; 1-O-Hexadecyl-2-lyso-sn-glycero-3-phosphocholine; 3-(Hexadecyloxy)-2-hydroxypropyl 2-(trimethylammonio)ethyl phosphate; sn-3-O-Hexadecyl-2-lyso-glycerophosphocholine; Palmitoyl Lyso-GPC (3-O-alkyl); LPC(16:0/0:0) (alkyl variant)
EINECS	Contact for details

Quality Control

Our 3-o-Hexadecyl-Sn-Glycero-1-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including NMR, HPLC, and MS to ensure structural identity and high chemical purity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, identity, and impurity profiles. Production can adhere to cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic and moisture-sensitive; ensure containers are allowed to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (NMR / HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.