Description

α-1-Antitrypsin (AAT) is a crucial serine protease inhibitor glycoprotein, primarily synthesized in the liver, that plays a vital role in regulating inflammatory processes and protecting tissues from enzymatic degradation. Its primary function is to inhibit neutrophil elastase, an enzyme that can break down connective tissue, making it essential for maintaining lung and liver integrity. This product is indispensable for pharmaceutical research, diagnostic development, and therapeutic applications, particularly in addressing conditions like α-1-Antitrypsin Deficiency (AATD).

Application

• Therapeutic Protein Development: As the active pharmaceutical ingredient (API) in augmentation therapy for patients with hereditary AAT deficiency.
• Biomedical Research: Used in studies of protease/anti-protease balance, inflammation, COPD, emphysema, and liver disease pathophysiology.
• Diagnostic Reagent Manufacturing: A key component in immunoassays and test kits for quantifying AAT levels in human serum.
• Cell Culture & Biochemistry: Employed as a supplement in specific cell culture media to inhibit proteolytic activity and stabilize sensitive proteins.
• Reference Standard: Serves as a high-purity standard for quality control in pharmaceutical production and clinical laboratory testing.
• Drug Delivery & Formulation Studies: Investigated in novel formulation strategies for pulmonary delivery and bioconjugates.

Basic Information

Product Name	α-1-Antitrypsin
CAS No.	9041-92-3
Molecular Formula	C21H32O5
Molecular Weight	~52 kDa (Glycoprotein)
Synonyms	α-1-Proteinase Inhibitor; α1-Antitrypsin; A1AT; AAT; SERPINA1; α1-Antiprotease; α-1-Antiproteinase; PI; Human α-1-Antitrypsin
EINECS	Contact for details

Quality Control

Our α-1-Antitrypsin is produced and tested under stringent quality systems. Each batch is characterized to ensure identity, purity, and functional activity, aligning with relevant guidelines for biological products. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for purity (by HPLC/SDS-PAGE), functional activity (elastase inhibition assay), endotoxin levels, and sterility where applicable.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized (freeze-dried) material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent degradation. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under controlled, dry conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (Immunological)	Conforms
Purity (SDS-PAGE, reduced)	> 95%
Assay (Functional Activity)	> 90% of stated activity
Protein Content (Biuret/UV)	≥ 90%
Endotoxin	< 1.0 EU/mg
Moisture (Karl Fischer)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.