Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine is a high-purity, synthetic phospholipid essential for constructing stable, biocompatible lipid membranes. This compound is a critical building block in advanced drug delivery systems, particularly for formulating liposomes and lipid nanoparticles (LNPs) that encapsulate sensitive therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, formulation scientists, and manufacturers in the life sciences sector for developing next-generation nanomedicines, vaccines, and diagnostic tools.

Application

• Liposome Formulation: A key structural phospholipid for creating stable, uniform liposomal vesicles for drug delivery.
• Lipid Nanoparticle (LNP) Systems: Used as a helper lipid or structural component in mRNA and siRNA delivery platforms, including COVID-19 vaccines.
• Biomimetic Membrane Research: Essential for creating model cell membranes (e.g., supported lipid bilayers) for biophysical and biochemical studies.
• Drug Encapsulation: Improves the loading efficiency and stability of hydrophobic and hydrophilic active pharmaceutical ingredients (APIs).
• Diagnostic Agent Carrier: Serves as a carrier for contrast agents and dyes in imaging and diagnostic applications.
• Cosmetic & Dermal Delivery: Employed in advanced cosmetic formulations for enhanced skin penetration and stabilization of active ingredients.
• Cell Culture & Transfection: Used in specialized cell culture media and as a component in transfection reagents.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine
CAS No.	923-61-5
Molecular Formula	C37H74NO8P
Molecular Weight	691.96 g/mol
Synonyms	DPPE; 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Dipalmitoylphosphatidylethanolamine; Phosphatidylethanolamine, 1,2-dipalmitoyl-; L-α-Phosphatidylethanolamine, dipalmitoyl-; PE(16:0/16:0); N-[1,2-Bis(hexadecanoyloxy)propyl]-2-aminoethyl dihydrogen phosphate
EINECS	213-097-1

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, TLC for identification, and specific tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed container to reach room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	190°C - 200°C
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.