Description

Pyrazinamide CAS NO 98-96-4 is a synthetic pyrazine derivative and a critical first-line antitubercular agent. Its primary value lies in its sterilizing activity against dormant *Mycobacterium tuberculosis* bacilli, making it indispensable for shortening the duration of tuberculosis treatment. This high-purity pharmaceutical intermediate is essential for manufacturers in the global pharmaceutical industry producing combination therapies for drug-sensitive and multi-drug resistant tuberculosis (MDR-TB).

Application

• Pharmaceutical Active Ingredient (API): Core component in fixed-dose combination (FDC) tablets for the standard 6-month TB treatment regimen.
• Antitubercular Drug Synthesis: Serves as the key building block in the synthesis of pyrazinamide and related analogs.
• Research & Development: Used in microbiological and pharmacological studies to develop new TB therapeutics and understand drug resistance mechanisms.
• Veterinary Pharmaceuticals: Employed in the treatment of mycobacterial infections in animals.
• Reference Standard: Sourced by analytical laboratories and pharmacopeial bodies for use as a high-purity calibration standard in HPLC and spectroscopic assays.

Basic Information

Product Name	Pyrazinamide
CAS No.	98-96-4
Molecular Formula	C5H5N3O
Molecular Weight	123.11 g/mol
Synonyms	Pyrazinecarboxamide; Pyrazinoic acid amide; PZA; Aldinamide; Zinamide; Tebrazid; Pirazinamid; 2-Pyrazinecarboxamide; Pyrafat
EINECS	202-716-8

Quality Control

Our Pyrazinamide is manufactured under strict quality management systems to ensure it meets the stringent requirements of the global pharmaceutical supply chain. We offer grades compliant with major pharmacopeial standards, including USP, EP, and BP. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and regulatory compliance for our B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.1%; Total impurities ≤ 0.5%
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.