Description

Protionamide CAS NO 14222-60-7 is a synthetic thiocarbamide derivative belonging to the class of second-line anti-tuberculosis agents. Its primary value lies in its targeted bacteriostatic activity against *Mycobacterium tuberculosis*, particularly in cases of drug-resistant strains. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing specialized tuberculosis treatment regimens.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of second-line anti-tuberculosis (TB) drugs for multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) tuberculosis.
• Clinical Research & Development: Used in preclinical and clinical studies to investigate new combination therapies and treatment protocols for resistant tuberculosis infections.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for the identification and assay of protionamide in finished drug products.
• Veterinary Pharmaceutical Research: Investigated for potential applications in treating mycobacterial infections in animals.
• Biochemical Research: Utilized as a tool compound in microbiological studies to understand the mechanism of action of thiocarbamide derivatives against bacterial cell walls.

Basic Information

Product Name	Protionamide
CAS No.	14222-60-7
Molecular Formula	C9H12N2S
Molecular Weight	180.27 g/mol
Synonyms	Prothionamide; 2-Propylpyridine-4-carbothioamide; 2-Propylisonicotinothioamide; PTH; 4-Pyridinecarbothioamide, 2-propyl-; Ektazid; Peteha; Trevintix; Tubermin; Tebuazid; Contact for other regional trade names.
EINECS	238-098-1

Quality Control

Our Protionamide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with relevant pharmacopoeial standards (e.g., USP, EP) and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.