Description

Capuramycin is a semisynthetic nucleoside antibiotic derived from the natural product A-500359s, belonging to the uridine family. This compound is a potent and selective inhibitor of bacterial translocase I (MraY), a key enzyme in the early stages of peptidoglycan biosynthesis, making it a valuable tool in antibacterial research and development. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on discovering novel mechanisms to combat drug-resistant Gram-positive bacterial infections, such as MRSA and VRE.

Application

• Antibacterial Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the discovery of new antibiotics targeting peptidoglycan synthesis.
• Mechanistic Studies: Used as a specific biochemical tool to study the function and inhibition of the bacterial enzyme translocase I (MraY).
• Microbiology & Pharmacology: Employed in in vitro and in vivo models to evaluate efficacy against resistant Gram-positive pathogens like methicillin-resistant Staphylococcus aureus (MRSA).
• Pharmaceutical Intermediates: Acts as a key intermediate or precursor in the synthetic pathways for more complex antibiotic analogs.
• Quality Control & Analytical Standards: Provides a high-purity standard for HPLC, LC-MS, and other analytical methods in pharmaceutical quality assurance laboratories.

Basic Information

Product Name	Capuramycin
CAS No.	102770-00-3
Molecular Formula	C26H38N6O11
Molecular Weight	610.62 g/mol
Synonyms	1-[(2R,3S,4R,5S)-5-(4-Amino-2-oxopyrimidin-1-yl-3,4-dihydroxyoxolan-2-yl]methyl-4-hexyl-3-[(2S,3S)-3-hydroxy-2-(methylamino)pentanoyl]oxy-1H-pyrrole-2-carboxylic acid; A-102395; (1S,2S)-trans-2-[(4-Amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyl]-4-hexyl-3-[(2S,3S)-3-hydroxy-2-(methylamino)-1-oxopentyl]oxy-1-[(1S)-1-hydroxyethyl]-1H-pyrrole-5-carboxylic Acid; Capuramycin disaccharide; Uridine antibiotic A-500359s derivative.
EINECS	Contact for details

Quality Control

Our Capuramycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, it is recommended to keep the material under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.