Description

Chlorpropamide CAS NO 94-20-2 is a first-generation sulfonylurea compound primarily recognized for its role as an oral hypoglycemic agent. Its core value lies in its ability to stimulate insulin secretion from pancreatic beta cells, making it a critical active pharmaceutical ingredient (API) for managing blood glucose levels. This product is essential for pharmaceutical manufacturers and research institutions developing and producing antidiabetic medications, particularly for type 2 diabetes mellitus. We supply high-purity chlorpropamide to meet the stringent requirements of global pharmacopoeial standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral antidiabetic tablets for the treatment of non-insulin-dependent diabetes mellitus (Type 2 Diabetes).
• Reference Standard: Serves as a certified reference material (CRM) for quality control laboratories performing HPLC, UV, or titration assays in pharmaceutical analysis.
• Biochemical Research: Used in metabolic studies to investigate insulin secretion mechanisms, pancreatic β-cell function, and sulfonylurea receptor activity.
• Formulation Development: Employed in R&D for developing new drug delivery systems, combination therapies, and generic drug formulations.
• Pharmacopoeial Compliance: Manufactured to meet the specifications of major pharmacopoeias such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia) for global market distribution.

Basic Information

Product Name	Chlorpropamide
CAS No.	94-20-2
Molecular Formula	C10H13ClN2O3S
Molecular Weight	276.74 g/mol
Synonyms	1-[(p-Chlorophenyl)sulfonyl]-3-propylurea; P-607; Diabinese; Chloronase; Glyburide (historical/related); Shui Tang Kang; N-Propyl-N'-(p-chlorobenzenesulfonyl)urea; 4-Chloro-N-[(propylamino)carbonyl]benzenesulfonamide
EINECS	202-314-6

Quality Control

Our Chlorpropamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets or exceeds the requirements of major pharmacopoeial standards, including USP and EP. Key parameters such as identification, assay (purity), related substances (impurities), and residual solvents are rigorously controlled. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.