Description

1-(4-Methylbenzyl)Piperidine-4-Carboxylic Acid is a high-purity, synthetically versatile organic compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both a piperidine carboxylic acid and a p-methylbenzyl group, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This product is primarily targeted at research and development (R&D) chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecular entities with specific biological or functional properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its piperidine core for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic and Industrial Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.
• Custom Synthesis Starting Material: Provided to contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	1-(4-Methylbenzyl)Piperidine-4-Carboxylic Acid
CAS No.	897094-27-8
Molecular Formula	C15H21NO2
Molecular Weight	247.33 g/mol
Synonyms	4-[(4-Methylphenyl)methyl]-4-piperidinecarboxylic acid; 1-[(4-Methylphenyl)methyl]piperidine-4-carboxylic acid; 1-(p-Methylbenzyl)isonipecotic acid; 1-(4-Methylbenzyl)-4-piperidinecarboxylic acid; 1-(4-Methylbenzyl)piperidine-4-carboxylic acid; 4-Carboxy-1-(4-methylbenzyl)piperidine; p-Methylbenzyl isonipecotate (precursor name); 897094-27-8 (CAS)
EINECS	Contact for details

Quality Control

Our production of 1-(4-Methylbenzyl)Piperidine-4-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research-grade chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.