Description

1-(2,5-Dichloro-Benzyl)-Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a defined chiral center, offering a critical building block for complex organic synthesis. Its value lies in its role as a versatile precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and agrochemical industries seeking to develop new drug candidates or crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of new drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, leveraging its halogenated aromatic and piperidine motifs.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities, structure-activity relationships (SAR), and novel synthetic pathways.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis & Contract Manufacturing: A critical component for companies offering bespoke chemical synthesis services for clients in the life sciences sector.

Basic Information

Product Name	1-(2,5-Dichloro-Benzyl)-Piperidine-3-Carboxylic Acid
CAS No.	896045-33-3
Molecular Formula	C14H15Cl2NO2
Molecular Weight	300.18 g/mol
Synonyms	1-[(2,5-Dichlorophenyl)methyl]piperidine-3-carboxylic acid; 3-Piperidinecarboxylic acid, 1-[(2,5-dichlorophenyl)methyl]-; 1-(2,5-Dichlorobenzyl)piperidine-3-carboxylic acid; 896045-33-3; 1-(2,5-Dichlorobenzyl)-3-piperidinecarboxylic acid; (R/S)-1-(2,5-Dichloro-benzyl)-piperidine-3-carboxylic acid; 1-(2,5-Dichlorobenzyl)nipecotic acid
EINECS	Contact for details

Quality Control

Our 1-(2,5-Dichloro-Benzyl)-Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.