Description

Ho-Peg12-Tbu CAS NO 892154-71-1 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group and a tert-butyl ester-protected carboxylic acid. This compound is a critical intermediate for the synthesis of advanced bioconjugates, enabling precise and stable linkages between biomolecules and other functional entities. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, protein and peptide modification, and surface functionalization.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching drugs, dyes, or other payloads to antibodies, proteins, and peptides.
• PEGylation Reagent: Used to introduce polyethylene glycol chains onto therapeutic molecules to improve solubility, stability, and circulation half-life.
• Drug Delivery System (DDS) Development: A key building block for constructing sophisticated nanoparticle carriers, liposomes, and polymer-drug conjugates.
• Surface Modification: Employed to create biocompatible, non-fouling coatings on medical devices, sensors, and diagnostic platforms.
• Functional Material Synthesis: Acts as a monomer or modifier in the creation of hydrogels, smart polymers, and other advanced materials with tailored properties.
• Proteomics and Diagnostics: Facilitates the labeling and immobilization of biomolecules for assay development and diagnostic tool fabrication.

Basic Information

Item	Detail
Product Name	Ho-Peg12-Tbu CAS NO 892154-71-1
CAS No.	892154-71-1
Molecular Formula	C31H62O15
Molecular Weight	674.8 g/mol
Synonyms	12-Amino-4,7,10-trioxadodecan-1-oic acid, 1,1-dimethylethyl ester; 1-tert-Butyl 12-hydroxy-4,7,10-trioxadodecanedioate; HO-PEG12-tBu ester; α-Hydroxy-ω-(tert-butoxycarbonyl)-tetraethylene glycol; 3,6,9,12-Tetraoxatetradecanedioic acid, 14-hydroxy-1,14-dioxo-, 1-tert-butyl ester; PEG12-OH-tBu-COOH; tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
EINECS	Contact for details

Quality Control

Our Ho-Peg12-Tbu CAS NO 892154-71-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.