Description

4-(3-Bromo-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in modern organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs) and advanced materials. Pharmaceutical researchers and fine chemical manufacturers need this intermediate for its reactive bromo and carbonyl functionalities, which enable precise structural modifications under controlled conditions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.
• Protease Inhibitor Development: Used in constructing pharmacophores for protease inhibitors due to the piperazine core and bromo-substituted benzoyl group.
• Ligand Synthesis for Catalysis: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and cross-coupling reactions.
• Peptidomimetic Chemistry: The tert-butyloxycarbonyl (Boc) protected piperazine is integral for building peptidomimetic scaffolds in medicinal chemistry.
• Agrochemical Research: Employed in the discovery and development of new crop protection agents and herbicides.
• Material Science: A building block for synthesizing functional polymers and advanced organic materials with specific electronic properties.

Basic Information

Product Name	4-(3-Bromo-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	890153-34-1
Molecular Formula	C16H21BrN2O3
Molecular Weight	369.26 g/mol
Synonyms	1-Boc-4-(3-Bromobenzoyl)piperazine; tert-Butyl 4-(3-bromobenzoyl)piperazine-1-carboxylate; 4-(3-Bromobenzoyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-bromobenzoyl)piperazine; N-Boc-4-(3-bromobenzoyl)piperazine; Piperazine-1-carboxylic acid, 4-(3-bromobenzoyl)-, 1,1-dimethylethyl ester; 890153-34-1
EINECS	Contact for details

Quality Control

Our 4-(3-Bromo-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.