Description

(E)-2-(4-Boc-Piperazin-1-Yl)-4-Cyclohexyl-3-Butenoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new drug candidates, particularly in areas requiring complex, functionalized piperazine derivatives.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce specific steric and electronic properties into candidate molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead sections of bifunctional PROTAC molecules for targeted protein degradation.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Scale-Up: Supplied for custom manufacturing projects, from milligram-scale research to multi-kilogram GMP production for clinical trials.

Basic Information

Product Name	(E)-2-(4-Boc-Piperazin-1-Yl)-4-Cyclohexyl-3-Butenoic Acid
CAS No.	890090-63-8
Molecular Formula	C19H32N2O4
Molecular Weight	352.47 g/mol
Synonyms	4-Cyclohexyl-2-[(4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl)methyl]-2-butenoic acid; 2-[(4-[(tert-Butoxycarbonyl)piperazin-1-yl]methyl]-4-cyclohexylbut-2-enoic acid; (E)-4-Cyclohexyl-2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)but-2-enoic acid; Boc-Piperazine Butenoic Acid Derivative; 890090-63-8; N-Boc-4-(2-Carboxy-3-cyclohexylallyl)piperazine
EINECS	Contact for details

Quality Control

Our (E)-2-(4-Boc-Piperazin-1-Yl)-4-Cyclohexyl-3-Butenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), chromatographic profiles, and physical characteristics are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.