Description

3-(4-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Research: Used as a building block for developing new pesticides, herbicides, and fungicides with enhanced efficacy.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for catalysis and metal complexation in fine chemical processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploratory chemistry in academic and industrial research settings.

Basic Information

Product Name	3-(4-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	889956-81-4
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl 3-(4-hydroxyphenyl)piperazine-1-carboxylate; 1-Boc-3-(4-hydroxyphenyl)piperazine; 3-(4-Hydroxyphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(4-hydroxyphenyl)piperazine; N-Boc-3-(4-Hydroxyphenyl)piperazine; 3-(4-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; 889956-81-4; Boc-3-(4-Hydroxyphenyl)piperazine
EINECS	Contact for details

Quality Control

Our 3-(4-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and production needs from laboratory to commercial scale, with capabilities for custom synthesis under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, prolonged storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.