Description

3-(3-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and receptor-targeting drugs. Pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers need this material to enable efficient, multi-step synthetic routes with high selectivity and yield.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting serotonin, dopamine, or adrenergic receptors.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and process development of complex molecules due to its protected amine and phenol functionalities.
• Custom Synthesis: Serves as a starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	3-(3-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	889956-76-7
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl 3-(3-hydroxyphenyl)piperazine-1-carboxylate; 1-Boc-3-(3-hydroxyphenyl)piperazine; 3-(3-Hydroxyphenyl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 3-(3-Hydroxyphenyl)piperazine-1-carboxylic Acid tert-Butyl Ester; 1-N-Boc-3-(3-Hydroxyphenyl)piperazine; 3-(3-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester; 3-(3-Hydroxyphenyl)piperazine-1-Boc
EINECS	Contact for details

Quality Control

Our 3-(3-Hydroxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.