Description

2-Chloro-7-Iodo-5H-Pyrrolo[2,3-B]Pyrazine is a high-value halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly in kinase inhibitor research and other targeted therapeutic areas. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Employed as a molecular probe or tag in biochemical and medicinal chemistry studies due to its reactive halogen sites.
• Material Science: Potential building block for organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Library Synthesis: Used in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	2-Chloro-7-Iodo-5H-Pyrrolo[2,3-B]Pyrazine
CAS No.	889447-20-5
Molecular Formula	C6H3ClIN3
Molecular Weight	279.46 g/mol
Synonyms	2-Chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine; 7-Iodo-2-chloro-5H-pyrrolo[2,3-b]pyrazine; 2-Chloro-7-iodopyrrolo[2,3-b]pyrazine; Pyrrolo[2,3-b]pyrazine, 2-chloro-7-iodo-5H-; 889447-20-5; AI3-34033; SCHEMBL218404; ZINC000006068770
EINECS	Contact for details

Quality Control

Our 2-Chloro-7-Iodo-5H-Pyrrolo[2,3-B]Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.