Description

tert-Butyl 4-(2-Aminobenzoyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with orthogonal protecting groups. This compound is critical for the synthesis of complex molecules, offering a versatile scaffold for medicinal chemistry research and drug development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable amine and carbonyl functionalities.
• Process Chemistry Development: Serves as a critical starting material for scaling up the production of complex therapeutic molecules under GMP conditions.
• Protease Inhibitor Synthesis: The piperazine-carboxylate structure is valuable in constructing scaffolds for protease inhibitor libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity intermediates.

Basic Information

Product Name	tert-Butyl 4-(2-Aminobenzoyl)Piperazine-1-Carboxylate
CAS No.	889125-00-2
Molecular Formula	C16H23N3O3
Molecular Weight	305.37 g/mol
Synonyms	1-Boc-4-(2-aminobenzoyl)piperazine; tert-Butyl 4-(2-aminobenzoyl)-1-piperazinecarboxylate; 2-Amino-N-(1-Boc-piperazin-4-yl)benzamide; 1-(tert-Butoxycarbonyl)-4-(2-aminobenzoyl)piperazine; 4-(2-Aminobenzoyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(2-aminobenzoyl)piperazine; N-Boc-4-(2-aminobenzoyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Aminobenzoyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.