Description

tert-Butyl 4-(2-Nitrobenzoyl)Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific heterocyclic and benzoyl-substituted structure. This compound is of critical importance in the synthesis of complex active pharmaceutical ingredients (APIs), where it serves as a key building block for introducing functionalized piperazine and aromatic motifs. It is primarily needed by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs), where its nitro and tert-butyloxycarbonyl (Boc) protected amine groups allow for selective chemical transformations.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a versatile scaffold for the creation of compound libraries.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up and optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of proprietary compounds for biotechnology and pharmaceutical clients.

Basic Information

Product Name	tert-Butyl 4-(2-Nitrobenzoyl)Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	889124-99-6
Molecular Formula	C16H21N3O5
Molecular Weight	335.36 g/mol
Synonyms	1-Boc-4-(2-nitrobenzoyl)piperazine; tert-Butyl 4-(2-nitrobenzoyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-nitrobenzoyl)piperazine; N-Boc-4-(2-nitrobenzoyl)piperazine; 4-(2-Nitrobenzoyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(2-Nitrobenzoyl)piperazine; 889124-99-6; 1-Piperazinecarboxylic acid, 4-(2-nitrobenzoyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Nitrobenzoyl)Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in global supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.