Description

4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile is a versatile and high-value pharmaceutical intermediate featuring a benzonitrile core linked to a hydroxypiperidine moiety. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing therapeutics for central nervous system (CNS) and other disease targets.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Serves as a building block in the production of Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Synthesis: Utilized in organic synthesis for introducing the 4-(hydroxypiperidin-1-yl)methyl) group into aromatic systems.
• Biochemical Tool Compound: Potential use in biochemical assays and as a reference standard for analytical method development.

Basic Information

Product Name	4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile
CAS No.	887593-88-6
Molecular Formula	C14H18N2O
Molecular Weight	230.31 g/mol
Synonyms	4-[(4-Hydroxypiperidin-1-yl)methyl]benzonitrile; 1-[(4-Cyanophenyl)methyl]-4-piperidinol; 4-(4-Hydroxy-1-piperidinylmethyl)benzonitrile; 4-(4-Hydroxypiperidin-1-ylmethyl)benzonitrile; Benzonitrile, 4-[(4-hydroxy-1-piperidinyl)methyl]-; 4-(Hydroxypiperidinomethyl)benzonitrile; 4-Cyano-N-(4-hydroxypiperidin-1-yl)methylbenzene
EINECS	Contact for details

Quality Control

Our 4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.