Description

2-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile is a versatile and high-value pharmaceutical intermediate featuring a benzonitrile core linked to a functionalized piperidine ring. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) due to its unique molecular scaffold, which allows for precise structural modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and oncology research domains.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• CNS Drug Development: Serves as a precursor for compounds targeting neurological disorders and psychiatric conditions.
• Oncological Research: Employed in the design and synthesis of potential kinase inhibitors and other anti-cancer agents.
• Chemical Synthesis: Acts as a versatile synthon for further chemical transformations, including reduction, hydrolysis, and coupling reactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile
CAS No.	887593-76-2
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	1-[(2-Cyanophenyl)methyl]-4-piperidinol; 4-Piperidinol, 1-[(2-cyanophenyl)methyl]-; 2-[(4-Hydroxypiperidin-1-yl)methyl]benzonitrile; 1-(2-Cyanobenzyl)-4-hydroxypiperidine; 2-((4-Hydroxypiperidin-1-yl)methyl)benzonitrile; Benzonitrile, 2-[(4-hydroxy-1-piperidinyl)methyl]-
EINECS	Contact for details

Quality Control

Our 2-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.