Description

1-Boc-3-([(4-Methyl-Piperazin-1-Ylpropyl)-Amino]-Methyl)-Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture with a Boc-protected pyrrolidine core linked to a methylpiperazine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of novel protease inhibitors.
• Kinase Inhibitor Synthesis: Employed in the construction of kinase inhibitor libraries for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Academic Research: Used in university and institutional labs for advanced organic synthesis methodology development and bio-conjugation studies.

Basic Information

Product Name	1-Boc-3-([(4-Methyl-Piperazin-1-Ylpropyl)-Amino]-Methyl)-Pyrrolidine
CAS No.	887591-45-9
Molecular Formula	C18H36N4O2
Molecular Weight	340.51 g/mol
Synonyms	1-Boc-3-[(3-(4-Methylpiperazin-1-yl)propylamino)methyl]pyrrolidine; tert-Butyl 3-({[3-(4-methylpiperazin-1-yl)propyl]amino}methyl)pyrrolidine-1-carboxylate; 1-(1,1-Dimethylethyl) 3-[[[3-(4-methyl-1-piperazinyl)propyl]amino]methyl]-1-pyrrolidinecarboxylate; 1-Boc-3-([(4-Methyl-1-Piperazinyl)Propyl]Aminomethyl)Pyrrolidine; N-Boc-3-((3-(4-methylpiperazin-1-yl)propylamino)methyl)pyrrolidine; 887591-45-9; Pyrrolidine, 1-[(1,1-dimethylethoxy)carbonyl]-3-[[[3-(4-methyl-1-piperazinyl)propyl]amino]methyl]-; 1-Boc-3-aminomethyl-N-(3-(4-methylpiperazin-1-yl)propyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-([(4-Methyl-Piperazin-1-Ylpropyl)-Amino]-Methyl)-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development with custom purity grades and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.