Description

1-Boc-3-[(4-Methyl-Piperazin-1-Ylethyl)-Amino]-Azetidine is a high-purity, advanced pharmaceutical intermediate featuring a protected azetidine core linked to a substituted piperazine moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced pharmacokinetic properties. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors targeting specific enzymatic pathways.
• GPCR Ligand Synthesis: Employed in the development of ligands for G-protein-coupled receptors relevant to various disease states.
• Kinase Inhibitor Scaffold: Integral component in the construction of heterocyclic scaffolds for kinase inhibition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Boc-3-[(4-Methyl-Piperazin-1-Ylethyl)-Amino]-Azetidine
CAS No.	887580-82-7
Molecular Formula	C15H30N4O2
Molecular Weight	298.43 g/mol
Synonyms	1-Boc-3-[(2-(4-Methylpiperazin-1-yl)ethyl)amino]azetidine; tert-Butyl 3-[(2-(4-methylpiperazin-1-yl)ethyl)amino]azetidine-1-carboxylate; 1-(1,1-Dimethylethyl) 3-[(2-(4-methyl-1-piperazinyl)ethyl)amino]-1-azetidinecarboxylate; 3-[(2-(4-Methylpiperazin-1-yl)ethyl)amino]azetidine-1-carboxylic acid tert-butyl ester; BOC-Azetidine-Piperazine Intermediate; AZD-0098 Intermediate (related); 887580-82-7
EINECS	Contact for details

Quality Control

Our 1-Boc-3-[(4-Methyl-Piperazin-1-Ylethyl)-Amino]-Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we support development projects requiring material produced under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.