Description

4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzamidine is a high-purity, advanced pharmaceutical intermediate characterized by its amidine and piperidine functional groups. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of protease inhibitors and other small-molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting serine proteases.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Serves as a core scaffold for developing inhibitors for enzymes like thrombin, trypsin, and factor Xa, relevant to anticoagulant and anti-inflammatory therapies.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and mechanism in biological systems.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for client projects.

Basic Information

Product Name	4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzamidine
CAS No.	887577-72-2
Molecular Formula	C13H19N3O
Molecular Weight	233.31 g/mol
Synonyms	4-[(4-Hydroxypiperidin-1-yl)methyl]benzenecarboximidamide; 4-(4-Hydroxy-1-piperidinylmethyl)benzamidine; 1-[(4-Amidinophenyl)methyl]-4-piperidinol; 4-(4-Hydroxypiperidin-1-ylmethyl)benzamidine; Benzamidine, 4-[(4-hydroxy-1-piperidinyl)methyl]-; 4-(4-Hydroxy-piperidin-1-ylmethyl)-benzenecarboximidamide; 4-(4-Hydroxy-1-piperidinylmethyl)benzenecarboximidamide
EINECS	Contact for details

Quality Control

Our 4-(4-Hydroxy-Piperidin-1-Ylmethyl)-Benzamidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.