Description

1-[2-Fluoro-4-(Methylsulphonyl)Phenyl]-4-(2-Hydroxyethyl)Piperazine is a high-value, functionalized piperazine derivative featuring a fluorinated phenylsulfone moiety and a terminal hydroxyethyl group. This unique molecular architecture makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D and manufacturing teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active compounds targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides and fungicides, leveraging its fluorinated aromatic structure.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and combinatorial chemistry libraries due to its modifiable piperazine and hydroxyethyl functionalities.
• Ligand and Catalyst Development: Employed in the design of specialized ligands for catalysis and molecular recognition applications.
• Fine Chemical Production: Acts as a starting material for the manufacture of other complex, high-value specialty chemicals.

Basic Information

Product Name	1-[2-Fluoro-4-(Methylsulphonyl)Phenyl]-4-(2-Hydroxyethyl)Piperazine
CAS No.	887453-53-4
Molecular Formula	C13H19FN2O3S
Molecular Weight	302.36 g/mol
Synonyms	4-(2-Hydroxyethyl)-1-[2-fluoro-4-(methylsulfonyl)phenyl]piperazine; 1-(2-Fluoro-4-methanesulfonylphenyl)-4-(2-hydroxyethyl)piperazine; 2-[4-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazin-1-yl]ethanol; FMPHP; 887453-53-4 (CAS)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this high-purity intermediate. Production adheres to cGMP guidelines where applicable, and every batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.