Description

7-Bromopyrido[2,3-b]pyrazine-8-carboxylic acid is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of complex molecules, particularly for drug discovery and development programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in creating novel therapeutic agents, especially within oncology and targeted therapy research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Kinase Inhibitor Development: Used in the construction of heterocyclic cores for potential kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	7-Bromopyrido[2,3-b]pyrazine-8-carboxylic Acid
CAS No.	887206-76-0
Molecular Formula	C8H4BrN3O2
Molecular Weight	254.04 g/mol
Synonyms	7-Bromo-8-carboxypyrido[2,3-b]pyrazine; 8-Bromo-7-carboxypyrido[2,3-b]pyrazine; 7-Bromopyrido[2,3-b]pyrazine-8-carboxylic acid; Pyrido[2,3-b]pyrazine-8-carboxylic acid, 7-bromo-; 887206-76-0; 7-Bromo-8-pyrido[2,3-b]pyrazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 7-Bromopyrido[2,3-b]pyrazine-8-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under quality agreements and can supply material suitable for use under ICH stability guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.