Description

3-Cyclobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in modern organic synthesis. Its core value lies in providing a versatile, nitrogen-containing scaffold with a cyclobutyl substituent, enabling the development of novel molecular architectures with specific three-dimensional characteristics. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct potential active pharmaceutical ingredients (APIs) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.
• Medicinal Chemistry Scaffold: Used to introduce the constrained cyclobutyl-piperazine moiety into lead compounds to modulate potency, selectivity, and pharmacokinetic properties.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and herbicides.
• Chemical Biology Probe Synthesis: Utilized in creating tool compounds for target validation and pathway analysis in biological systems.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for bespoke synthesis projects requiring advanced, protected heterocyclic amines.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	3-Cyclobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886780-01-4
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	1-Boc-3-cyclobutylpiperazine; tert-Butyl 3-cyclobutylpiperazine-1-carboxylate; N-Boc-3-cyclobutylpiperazine; 1-(tert-Butoxycarbonyl)-3-cyclobutylpiperazine; 3-Cyclobutyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Boc-3-cyclobutylpiperazine; 886780-01-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-Cyclobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (NMR, IR, MS), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.