Description

2-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for API synthesis and novel compound discovery.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) agents, antivirals, and other bioactive molecules containing the piperazine scaffold.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the cyclopropyl and piperazine motifs can contribute to unique biological activity.
• Chemical Biology & Medicinal Chemistry: Employed as a building block for creating focused libraries of compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetics & Drug Design: The tert-butyloxycarbonyl (Boc) protecting group makes it invaluable for the stepwise synthesis of complex peptides and peptidomimetics.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886779-93-7
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 2-cyclopropylpiperazine-1-carboxylate; 1-Boc-2-cyclopropylpiperazine; 2-Cyclopropyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-2-cyclopropylpiperazine; N-Boc-2-cyclopropylpiperazine; 2-Cyclopropylpiperazine-1-carboxylic acid tert-butyl ester; Boc-2-cyclopropylpiperazine; 886779-93-7
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.