Description

tert-Butyl 2-(Trifluoromethyl)Piperazine-1-Carboxylate is a high-value, protected piperazine derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in the strategic combination of a Boc-protected amine for selective deprotection and a trifluoromethyl group, which is highly sought after for its ability to modulate the physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where enhanced metabolic stability, lipophilicity, and bioavailability are desired.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs, kinase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Peptidomimetics & Bioactive Molecule Design: The piperazine scaffold is incorporated to create novel peptide mimics and other bioactive compounds for drug discovery programs.
• Ligand & Catalyst Development: Serves as a starting material for constructing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialty polymers with unique fluorinated properties.

Basic Information

Product Name	tert-Butyl 2-(Trifluoromethyl)Piperazine-1-Carboxylate
CAS No.	886779-77-7
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	1-Boc-2-(trifluoromethyl)piperazine; tert-Butyl 2-(trifluoromethyl)-1-piperazinecarboxylate; 2-(Trifluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-(trifluoromethyl)piperazine; Boc-2-CF3-piperazine; N-Boc-2-trifluoromethylpiperazine; 1-N-Boc-2-trifluoromethylpiperazine; 2-Trifluoromethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Trifluoromethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the rigorous demands of research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (HPLC), identity (NMR, IR), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.