Description

3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in the trifluoromethyl group, which is strategically incorporated into target molecules to enhance their metabolic stability, lipophilicity, and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, especially in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Peptidomimetics & PROTACs: Serves as a versatile scaffold for constructing peptidomimetic compounds and Proteolysis Targeting Chimeras (PROTACs) in drug discovery.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands for asymmetric catalysis and organometallic complexes.
• Material Science Research: Acts as a precursor for specialty polymers and advanced materials with unique fluorinated properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects and scale-up activities.

Basic Information

Product Name	3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886779-69-7
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	1-Boc-3-(trifluoromethyl)piperazine; tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate; 3-(Trifluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-trifluoromethylpiperazine; N-Boc-3-(trifluoromethyl)piperazine; 3-Trifluoromethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Boc-3-CF3-piperazine
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that batch. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet your project's exact requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.