Description

tert-Butyl 3-(Thien-2-Yl)Piperazine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-3-(Thien-2-Yl)Piperazine is a high-value, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the efficient construction of complex molecules with potential therapeutic activity. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the piperazine-thiophene pharmacophore.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns for constructing diverse compound libraries via parallel and combinatorial synthesis.
• API Development: Serves as a protected intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), where the Boc (tert-butoxycarbonyl) group provides orthogonal protection.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Agrochemical Synthesis: Potential intermediate in the research and development of novel crop protection agents and pesticides.
• Material Science Research: Can be utilized as a monomer or functional component in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	tert-Butyl 3-(Thien-2-Yl)Piperazine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-3-(Thien-2-Yl)Piperazine
CAS No.	886771-38-6
Molecular Formula	C13H20N2O2S
Molecular Weight	268.37 g/mol
Synonyms	1-Boc-3-(2-Thienyl)piperazine; 1-(tert-Butoxycarbonyl)-3-(2-thienyl)piperazine; tert-Butyl 3-(2-thienyl)-1-piperazinecarboxylate; 3-(Thiophen-2-yl)-1-piperazinecarboxylic acid tert-butyl ester; 1-N-Boc-3-(2-thienyl)piperazine; 886771-38-6; 3-(2-Thienyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Boc-3-(2-thienyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Thien-2-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to support research and regulatory documentation needs. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability, or at controlled room temperature (15-25°C) for short-term use. Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.