Description

3-(3,5-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its molecular structure, featuring a difluorophenyl group and a Boc-protected piperazine, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances bioactivity and stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring a fluorinated, protected piperazine core.

Basic Information

Product Name	3-(3,5-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-90-7
Molecular Formula	C15H20F2N2O2
Molecular Weight	298.33 g/mol
Synonyms	tert-Butyl 3-(3,5-difluorophenyl)piperazine-1-carboxylate; 1-Boc-3-(3,5-difluorophenyl)piperazine; 3-(3,5-Difluorophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-(3,5-difluorophenyl)piperazine; 886768-90-7; 3-(3,5-Difluorophenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(3,5-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.